![]() The trial’s primary endpoint was overall survival. Men in the trial were randomly assigned to receive either radium-223 (six intravenous injections, one every 4 weeks) plus the best standard of care or a placebo plus the best standard of care. The Alpharadin in Symptomatic Prostate Cancer Patients (ALSYMPCA) trial enrolled 921 patients with metastatic, castration-resistant prostate cancer. Once the drug, which can be given intravenously, reaches bone, it emits very low levels of radiation that travel less than 100 microns, or approximately four one-thousandths of an inch, limiting damage to the surrounding tissues. Radium-223 is a “calcium mimetic” that, like calcium, accumulates preferentially in areas of bone that are undergoing increased turnover, such as areas where bone metastases are forming. The alpha particle radiation causes double-strand breaks in DNA, killing cells. Radium-223 dichloride (radium-223) is a radioactive isotope that emits low levels of alpha particle radiation. ![]() Several drugs have been approved by the Food and Drug Administration (FDA) to prevent pain and fractures in patients with bone metastases, but none of these drugs improves the survival of men with prostate cancer. Bone metastases can cause intense pain, weakness, and bone fractures, greatly impairing quality of life-and in some cases causing death. ![]() In most men with metastatic castration-resistant prostate cancer-prostate cancer that no longer responds to hormone therapy-the cancer spreads (metastasizes) to the bones. New England Journal of Medicine ( NEJM), J(See the journal article.) Background Results from a phase III trial called ALSYMPCA show that radium-223 dichloride (Xofigo®) improves overall survival in men with advanced prostate cancer that has spread to their bones compared with a placebo.
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![]() While you can hear it slowly coming, it still takes you by surprise when it arrives. Probably the best attribute you can assign to Dredg is change of tempo they induce in their songs. One moment your being carressed by a smooth ly flowing waterfall of sound and all of a sudden, BAM! you have some hardcore stuff going down. They have no style that presents itself in every song, but you can easily pinpoint a tune and brand it "Dredg". HOWEVER, if you enjoy music with crushing guitar riffs, smooth acoustic strummings, and even a little piano, you in the right place.Dredg is like several bands in one. Who is Dreg? Where in the hell did they come from? Will anyone ever produce music like this again?To mainstream music listners, Dredg may be a little too "artsy fartsy" or "out there". Rarley does a band capture someones attention so easily without any warning that you cant lift a finger to hit the "stop" button. I must have listened to this album 10 or 15 times within the few days of my purchase. Thats a pretty acurate summary of my reaction when the last track of this CD ended. ![]() This is such a strange blend that it's hard to feel like you can do it justice in a "maximum of 1,000 words." They say a picture is worth 1,000 words, and dredg has insinuated that their music is like painting with sound, so how exactly does that all figure out? All I know is that it's an incredible journey for the mind and the heart, and I encourage everyone to take it at least once, with ears and mind wide open." It's hard to sum up the feeling of listening to this album in mere words, for this is no straightforward 4/4 radio-formatted rock garbage we're talking about. Everyone is a part, and yet there is no focused center. Where we are not limited in class, culture, style or creed. Somewhere where wise men journey the earth and bring back their knowledge to share with you. It plays both sides, it's at times as hard rock as they've ever been, but at other times it's so lush, so amazingly deep that you almost forget you're listening to a compact disc and start to drift off into another world. For those who are well-versed in the band's history, you can see where their past plays in and where their future is hinted at in this album. A step up in lyrical and musical maturity, a step up in song structure and a step up in having a coherent theme to tie the album together as a whole. "Despite earlier demos, this is really where it all began for dredg. It's as good as Leitmotif except the tracks are well recorded.So for everyone you likes music for it's grace and poetic meaning and not for it's cheap gimics, lame beats and sell-out artists, I highly suggest you to buy this album soon and get ready to look at music in a way you never looked at it before." If you have this album, download Of the Room, the new Dredg demo for their next album in April 2002. But it's still worth buying buying for sure for any random music fan. Songs like Lechium and Yatahaze are extreamly graceful and poetic, but they still have the hard rock edge.Gavin has great singing voice for this type of music, but since this was recorded as an indie record in 1999 or 1998 and now re-releast in 2001, the voice track isn't that great. The music and art work in this album aren't comparable to anyother band, even Tool and Radiohead which are 2 bands i really really like! It starts of with "Symbol Song" and from their it takes you on a musical journey. "This is by far the best CD i ever owned. File integrity check test to ensure whether an archive is damaged or not.Availability of ZIP & RAR format archive comment.Supported formats: 7Z, ACE, AES, ALZ, ARJ, BH, BIN, BR, BZ, BZ2, CAB, Compound(MSI), DAA(1.0), DEB, EGG, GZ, IMG, ISO, ISZ, LHA, LZ, LZH, LZMA, PMA, RAR, RAR5, SFX(EXE), TAR, TBZ/TBZ2, TGZ, TLZ, TXZ, UDF, WIM, XPI, XZ, Z, ZIP, ZIPX, ZPAQ, PEA, UU, UUE, XXE, ASAR, ZSTD, and NSIS.Multi-volume archive creation of ZIP/7z format.Unicode or MBCS filename for ZIP format.Supports compression of 4GB+ size files.Up to 6 times faster compression using multi-core.ZIP file modification (add/delete/rename).Supported formats: ZIP, 7Z(lzma2), ZIPX(xz), EXE(sfx), TAR, TGZ, LZH(lh7), ISO(joliet), GZ, and XZ.I switched to PeaZip, but there are also 7-Zip and other programs that are readily available.Detect malware in an archive by safe and accurate antimalware scan Others may prefer to use free alternatives that don't display advertisement. Some users may not mind the advertisement, as it can be avoided by not opening the main interface. The free version displays advertisement in the main interface in other words: nothing has changed in this regard. Closing Wordsīandizip's latest version, version 7.13, has the same limitations as the version that I reviewed back in March 2020. Most changes, however, fix bugs and issues in the application. when they are moved from one screen to another. Users who don't open the program directly, by using the context menu to extract or create files, may never see advertisement when they use the program.Ī quick look at the program's version history shows several new version releases since the release of Bandizip 7.0. Bandizip 7.06 introduced support for Windows 10's Per-Monitor V2 DPI Awareness feature to make sure that program windows scale automatically when the resolution changes, e.g. It makes the interface look quite messy.Īdvertisement is not displayed when you open archives or when you extract them. The main Bandizip interface displays an advertisement banner in the top lower right corner and a register icon in the upper left corner. It may be used in commercial environments on the other hand as well. The terms that are displayed when you run the installer reveal that the free version is limited when it comes to certain features (the ones mentioned above), and that advertisement is displayed. Advertisement is still listed as non-removable in the free version. Sure, it would be lovely if all features were also present in the free version, but companies need to earn revenue to finance the continued development of the application, and one way of doing so, is to make sure that the commercial versions are attractive from a feature point of view. Has anything changed since the release of Bandizip 7? Bandizip, the second lookĪ look at the Bandizip homepage confirms that the limitations of the free version are still all there this is not that much of a problem in my opinion, as the features were not part of previous versions. To the developer's credit, the features that are limited or not available have not been available in previous versions of Bandizip. These features, the option to repair archives, password recovery, password management, antimalware scan, or image previews in archives, are not included in the free version at all or severely limited (only one password can be stored in the Standard Edition password manager). The free version came with limitations the company did not take away features, but it excluded the free version from having new features that it unlocked only in the commercial versions. An Enterprise version was also added to the lineup. Bandizip would be offered as a free and commercial product, and the free product would get advertisement and would only be provided as an online installer.īandizip 7.0 launched on March 3, 2020, and with it came the free version, now called Standard Edition, and the commercial version, called Professional Edition. This led to my 2014 review of Bandizip in which I expressed the opinion that it was probably the best file archiver for Windows at the time my opinion did not change until late 2019 when the company behind the product announced major changes coming to Bandizip 7. It was convenient to use, supported all the archive types that I required, and did not put any distractions on the screen while it was being used. The file archiver Bandizip was my go-to program on Windows for all file archive related operations for a long time. ![]() But the rise of rapid home tests - and general waning of public interest in testing at all - has all but erased the ability to grasp current case counts nationwide. Tracking Covid-19 trends has always had its challenges. And IHME estimates from that time suggest that the US was in one of the worst waves of the pandemic, second only to the Omicron surge. In mid-December, the US Centers for Disease Control and Prevention was reporting about 500,000 cases a week. Mokdad declined to quantify an estimate for current case counts, but he said he’s been getting lots of calls and questions about Covid-19 recently - similar to what he experienced around the end of last year. “We felt that the margin of error became really too big for us to make a prediction that we could stand by and defend.” “The surveillance system was not adequate anymore to capture changes in Covid-19,” he said. ![]() It may be time to break out the masks against Covid, some experts sayĪll of the measures that factored into the model had stopped being reported or had changed in some way, said Ali Mokdad, professor of health metrics sciences and chief strategy officer of population health at the University of Washington. But the research institute paused that modeling in December.Ī mid adult female, standing outside places an N95 mask on her face for protection during the pandemic. ![]() “And we should be paying attention to it, because we are starting to see an increase.”įrom 2020 to 2022, the University of Washington’s Institute for Health Metrics and Evaluation produced regular estimates of Covid-19 case rates and projections for trends. “There is more transmission out there than what the surveillance data indicates,” said Janet Hamilton, executive director of the Council of State and Territorial Epidemiologists. Rates of severe disease may be staying at relatively low levels, but experts agree that there are probably more infections than the current surveillance systems can capture. “We have several folks down with Covid, unfortunately,” one health-focused nonprofit told CNN when seeking comment for this story. Here’s how to think about risk from the virus now Crowd of people huddled together, overhead view - stock photo Daly and Newton/The Image Bank RF/Getty ImagesĬovid-19 has changed and so has our immunity. It is important to begin a treatment program as early as possible.Īfter a CP diagnosis is made, a team of health professionals works with the child and family to develop a plan to help the child reach his or her full potential. There is no cure for CP, but treatment can improve the lives of those who have the condition. Top of Page Treatments and Intervention Services The most common type of mixed CP is spastic-dyskinetic CP. Some people have symptoms of more than one type of CP. They might have a hard time controlling their hands or arms when they reach for something. They might have a hard time with quick movements or movements that need a lot of control, like writing. People with ataxic CP have problems with balance and coordination. A person with dyskinetic CP has muscle tone that can change (varying from too tight to too loose) not only from day to day, but even during a single day. Sometimes the face and tongue are affected and the person has a hard time sucking, swallowing, and talking. The movements are uncontrollable and can be slow and writhing or rapid and jerky. People with dyskinetic CP have problems controlling the movement of their hands, arms, feet, and legs, making it difficult to sit and walk. People with spastic quadriparesis usually cannot walk and often have other developmental disabilities such as intellectual disability seizures or problems with vision, hearing, or speech.ĭyskinetic Cerebral Palsy (also includes athetoid, choreoathetoid, and dystonic cerebral palsies) Spastic quadriplegia/quadriparesis―Spastic quadriplegia is the most severe form of spastic CP and affects all four limbs, the trunk, and the face.Spastic hemiplegia/hemiparesis―This type of CP affects only one side of a person’s body usually the arm is more affected than the leg.People with spastic diplegia might have difficulty walking because tight hip and leg muscles cause their legs to pull together, turn inward, and cross at the knees (also known as scissoring). Spastic diplegia/diparesis―In this type of CP, muscle stiffness is mainly in the legs, with the arms less affected or not affected at all.Spastic CP usually is described by what parts of the body are affected: This means their muscles are stiff and, as a result, their movements can be awkward. People with spastic CP have increased muscle tone. Spastic CP affects about 80% of people with CP. The most common type of CP is spastic CP. There are four main types of CP: Spastic Cerebral Palsy ![]() Depending on which areas of the brain are affected, one or more of the following movement disorders can occur: Many also have related conditions such as intellectual disability seizures problems with vision, hearing, or speech changes in the spine (such as scoliosis) or joint problems (such as contractures).ĭoctors classify CP according to the main type of movement disorder involved. CP does not get worse over time, though the exact symptoms can change over a person’s lifetime.Īll people with CP have problems with movement and posture. ![]() A person with mild CP, on the other hand, might walk a little awkwardly, but might not need any special help. A person with severe CP might need to use special equipment to be able to walk, or might not be able to walk at all and might need lifelong care. The symptoms of CP vary from person to person. CP is caused by abnormal brain development or damage to the developing brain that affects a person’s ability to control his or her muscles. Palsy means weakness or problems with using the muscles. Cerebral means having to do with the brain. ![]() CP is the most common motor disability in childhood. Cerebral palsy (CP) is a group of disorders that affect a person’s ability to move and maintain balance and posture. Tuna or Salmon Snack PacksĪs an easy protein snack to pack as you travel, we suggest grabbing the variety pack of Starkist Tuna and Salmon Creations. Shop: Nature’s Bakery Chocolate Oat Baked-Ins - $6.00 9. Want a healthy alternative to a snack cake, then you have to give Baked-Ins a try! With their brownie-like texture, you can satisfy your sweet tooth without the guilt. Shop: Chewy Granola Bars, Chocolate Chip - $5.79 8. Granola bars typically contain healthy ingredients like nuts, seeds, dried fruit, and whole grains. Look for granola bars with less than 230 calories per bar and at least 6 grams of protein. And, they can pack a lot of energy in each bar. Granola bars are a popular choice for non-perishable foods because they’re often high in protein. Shop: Chewy Fruit Leather, Orchard Blend - $3.74 7. Made with clean ingredients, the natural sweeteners and texture make this an addictive healthy snack when on the go. Fruit LeatherĪnother popular choice among travelers is fruit leather. Shop: Forager Project Organic Vegetable Chips - $9.73 6. They’re also gluten-free, non-GMO certified, soy-free, dairy-free, and vegan. As you travel, you can take them with you and feel good knowing you are snacking on something healthy. They can be found in most stores these days, and they come in various flavors. When you’re on the go and need some quick and healthy snacks, veggie chips are your best bet. Not to mention, they support healthy blood sugar levels and digestion. They are high in fiber and full of protein. Roasted chickpeas are an excellent choice for people who like hummus. They also contain magnesium, zinc, iron, vitamin B1 (Thiamin), and dietary fiber. One ounce of pumpkin seeds contains 6 grams of protein. ![]() Pumpkin seeds are a great source of protein, which is especially important for active people. Shop: Almond Butter Squeeze Packs - $35.70 3. These spreads are very high in calories, so you'll benefit from a few servings throughout the day. Be sure to choose an unsalted variety like almond or cashew butter. Nut butters are healthy and pack a ton of flavor, so you won't even miss other snacks. ![]() Tired of eating dry foods? Try packing some nut butter. Shop: Nature's Garden Healthy Trail Mix Snack $19.70 2. Just be sure to compare nutritional labels so you can pick out one of the best options available! This will give you enough energy to survive the day without feeling weighed down. Most healthy brands pack anywhere from two to three servings per container. No matter your preferences, there’s a trail mix for you. The best part? You can pick your ingredients to create the perfect blend. It has a variety of nuts, seeds, and dried fruit. The go-to choice for any traveler is trail mix. We'll also provide some tips on how to pack them so that you can stay well-fed while on your trip! 1. ![]() In this article, we will discuss the best non-perishable foods for travel. These foods are perfect for travel because they don't need refrigeration and they won't spoil. ![]() You don’t want to be stuck without anything to eat when you're on the go! That's why it's important to pack some non-perishable foods. When planning a trip, one of the most important things to consider is what you will eat. ![]() Products can be returned only in the country or region in which they were originally purchased.In that unlikely event, we invite you to review the following terms related to returning a product.įor any undamaged product, simply return it with its included accessories and packaging along with the original receipt (or gift receipt) within 14 days of the date you receive the product, and we’ll exchange it or offer a refund based upon the original payment method. We understand, however, that sometimes a product may not be what you expected it to be. ![]() That’s because we go out of our way to ensure that they’re designed and built to be just what you need. We fundamentally believe you will be thrilled with the products you purchase from the Apple Store. System Requirements for Learn to Play lessonsĭouble check to ensure you have the right system requirements to download and play Learn to Play lessons. Please read the product information for Electronic Software Downloads and Apple’s Sales and Refund Policy carefully, as software download purchases are non-refundable. If you’re having trouble previewing or playing Artist Lessons you’ve purchased, or have questions about system requirements, please contact AppleCare Technical Support at 1-80. If you’re having trouble purchasing, downloading, or retrieving Artist Lessons, please contact Apple Store Customer Service at 1-80. View and re-download your Artist Lesson purchases by visiting the Order History section of Your Account.Re-open GarageBand and your content will resume downloading where it left off.If your Artist Lesson does not automatically begin downloading, you quit GarageBand before your lesson finished downloading, or you do not see your purchased lessons in GarageBand, there are a few ways to retrieve your content: Once your lesson is downloaded, click Play to enjoy!.The Learn to Play area launches, where you can see your lesson being downloaded.Enter your payment information, and click the “Buy Now” button.Refer to the Your Account section of Online Help to learn more about the benefits of an Apple ID, or to find/reset your Apple ID or password. Note: If you don’t have an Apple ID, click the “create an Apple ID” link and follow the instructions. You’ll be asked to sign-in with your Apple ID and password. When you purchase Artist Lessons, you receive your content instantly! Once you’re in the Lesson Store and you find the Artist Lesson you like, simply click the Buy Now button. Purchasing and Downloading Artists Lessons To preview lessons, click anywhere in the rectangle (except the “Buy Now” button).Click either the Basic Lessons or Artist Lessons tab in the main area of the window.Launch GarageBand, and click on the Lesson Store tab.You can preview Basic Lessons before you download them and Artist Lessons before you purchase them. To preview new content or make new purchases, go to the Lesson Store.You can play the free and purchased content you’ve downloaded.Launch GarageBand, and navigate to the Learn to Play area.To play a Basic Lesson or purchased Artist Lesson: GarageBand allows you to create and record music, make podcasts, and play with your own virtual band! Learn more about iLife and GarageBand. Learn to Play lessons are great way to to enhance your ability to make music and are available exclusively through GarageBand, which is included in Apple’s iLife software suite of applications. Please read the product information for Electronic Software Downloads and Apple’s Sales and Refunds Policy carefully, as software download purchases are non-refundable. to 8:00 p.m., or Saturday - Sunday from 7:00 a.m. For support for OS X Snow Leopard refer to Snow Leopard Support.įor technical issues, you can visit to connect directly with an Apple Expert for assistance.įor questions about billing, orders, or your account, please contact Apple Store Customer Service at 1-80, Monday - Friday from 5:00 a.m.For support for OS X Lion refer to Lion Support.For support for OS X Mountain Lion refer to Mountain Lion Support.When ordering Lion or Mountain Lion, you will receive an email with a redemption code for use with the Mac App Store.If you need older versions of OS X, they can be purchased on the Apple Online Store: The current version of the Mac operating system is macOS Catalina. ![]() Baldur's Gate / Baldur's Gate: Enhanced Edition / Baldur's Gate II: Shadows of Amn / Baldur's Gate II: Enhanced Edition / Baldur's Gate: Enhanced Edition Trilogy (mod) (Enemy Randomizer).Azure Dreams (Game Boy Color) (pro_grammar's).Axiom Verge (Pozzum's) - Version 0.6.2.1 also contained an unbalanced monster randomizer - OBSOLETE.Gensôkyô no Nazo (fangame) (Ryason55's).An Untitled Story (Mokesmoe's) - Support available on the ESA Randomizer Discord server.Super Adventure Island II (abyssonym's).Adventure - See at end of list: Multi-series, Connected worlds. ![]() Yakuza: Like a Dragon (Enemy Randomizer)įor older changes, you may consult the full changelog.NEO: The World Ends with You (SaltContainer's).Mega Man Battle Network (Legacy Collection) (Undernet-Trader).Advance Wars 2: Black Hole Rising (Ephraim225's).Pokémon HeartGold Version / Pokémon SoulSilver Version (added to Universal Warp Randomizer) - Source code.DLC Quest / Noita (added to Archipelago).Halo 3 (The Master Chief Collection) (NPC Weapon Randomzier) - Also on Steam Workshop.Fire Emblem Engage (A Little *Secret* Ingredient).Age of Empires II: The Age of Kings / Age of Empires II (2013) / Age of Empires II: Definitive Edition (HyperRandom).Halo: Combat Evolved Anniversary (The Master Chief Collection) (Enemy Randomizer).Titanfall 2 (taskinoz's) - Official hints for new possible helmet locations.Pokémon Emerald EX Speedchoice (hack) (Map Rando) - Source code part 1, part 2.Inazuma Eleven GO Chrono Stones: Wildfire / Inazuma Eleven GO Chrono Stones: Thunderflash (Pixzer) - Support and potential future versions available on the Victory Road Discord server in the #ie-randomizer channel.Inazuma Eleven / Inazuma Eleven 2: FireStorm / Inazuma Eleven 2: Blizzard / Inazuma Eleven 3: Team Ogre Attacks! (Nintendo DS / Nintendo 3DS) (Ultimate Randomizer) - Support and potential future versions available on the Victory Road Discord server in the #ie-randomizer channel.Front Mission 5: Scars of the War (Khalid_SA's).Final Fantasy IV (pixel remaster) (Falcon Dive).Dark Souls II: Scholar of the First Sin (Scrambler). ![]()
Lazy pump manufacturers, leave that spring exposed in the water way behind the impeller, rendering it vulnerable to abrasive wear and to collecting stringy material & debris. Also, in order for mechanical seals to work, they all utilize a stainless steel compression spring to hold the seal faces together. Our seals have a large inside diameter with a lot of space between the seal and the shaft preventing seal damage from shock. When a hard piece of debris (rock, wood, etc) hits the pump impeller, it deflects the shaft momentarily and fractures the seal. Small diameter seals fit snug on the drive shaft. We also make the seal much larger in diameter than those found in most “trash pumps”. Silicon carbide is a premium seal material that is utilized in most industrial grade pumps. The Mini dredge pump is equipped with an oversized silicon carbide shaft seal. A leaky shaft seal will disable your pump completely, by allowing air to enter the pump case instead of water being drawn up the suction hose. The shaft seal is the component that seals the engine shaft as it enters the pump case. Carbon/ceramic is the cheapest seal material there is and is a strong indication that your pump is designed to pump water only. Cheap trash pumps usually utilize small diameter carbon/ ceramic shaft seals. The agitator water jet system is necessary to deliver kinetic energy (energy of motion) to the sediment to take it from a solid state rendering it a fluid slurry.Ĭheap trash pumps are not designed to withstand abrasion or shock. Get in touch! We will answer as soon as possible.First of all, a self priming pump alone is not very effective in removing sediment. Also, for other questions you can reach us. If you have any questions regarding renting or purchasing a Maintenance dredging platform, please do not hesitate to ask us! At Modular Pontoon Systems we are always happy to help. Look at our project page to see projects we have been working on in Portugal, the Bahamas, Ukraine, Kazakhstan and Panama. This is exactly how for the past 10 years we have been able to build an extensive and varied track record of projects. Wherever you are, wherever you go, MPS works alongside our customers anywhere in the world. Our strength is making our equipment available for worldwide deployment. All our pontoons are Bureau Veritas certified for use on inland waters up to coastal areas. We create our products with care and follow strict protocols and ISO standards. MPS is mostly known as an exclusive manufacturer of container pontoons, as well sectional workboats and jack-ups. Everything we do we do in-house, that is how we can come up with quick solutions. ![]() We do this from our head office in the Netherlands with a team of experienced engineers and designers. We always strive to meet our customers requirements and needs the best way possible. Whether you are seeking a maintenance dredging platform or additional deck service equipment such as a crane mat, guide rollers or a Hydraulic Power Unit, you can have full confidence in our commitment to those we serve. MPS is your partner for anything you need. Get in touch! We are happy to help! Maintenance dredging | MPS is your partner! MPS offers tailored made solutions based on our expertise and in-house design and manufacturing facilities. Do you need help in finding the right equipment for your project? Do not worry! We are here to help. This variety of equipment can be used for companies in the dredging, civil construction, oil & gas and offshore industries. Next to maintenance platforms we also offer new and used container pontoons, modular workboats, self-elevating platforms and deck equipment. Are you looking for a maintenance dredging platform? Modular Pontoon Systems has them available for purchase or rental. |
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